Protein tau

Protein tau (Inggris: microtubule-associated protein tau, MAPT) adalah protein yang membuat mikrotubula menjadi stabil. Protein tau terdapat sangat banyak pada neuron di dalam sistem saraf pusat, dan jarang terdapat di lokasi lain.

Protein tau berinteraksi dengan:

domain SH3 dari Fyn kinase, sebuah enzim dengan peran penting dalam proses mielinasi dan diferensiasi morfologis oligodendrosit^[1]
domain terminus-C sinuklein-alfa, sebuah protein yang terdapat dalam patogenesis beberapa kelainan saraf seperti penyakit Parkinson dan lesi seperti badan Lewy. Sinuklein-alfa kemudian menstimulasi protein kinase A untuk menginduksi fosforilasi protein tau.^[2] Proses fosforilasi juga dikatalisasi oleh cAMP-dependent protein kinase setelah protein tau terikat pada protein 14-3-3zeta.^[3]
domain pengikat seng dari protein S100.^[4]^[5]

Rujukan[sunting | sunting sumber]

^ (Inggris) "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". Departments of Neurobiology and Immunology, University of Heidelberg; Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J. Diakses tanggal 2010-06-27.
^ (Inggris) "alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356". Department of Medical Biochemistry, University of Aarhus; Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R. Diakses tanggal 2010-06-27.
^ (Inggris) "14-3-3zeta is an effector of tau protein phosphorylation". Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University; Hashiguchi M, Sobue K, Paudel HK. Diakses tanggal 2010-06-27.
^ (Inggris) "S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease". Centre for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto; Yu WH, Fraser PE. Diakses tanggal 2010-06-27.
^ (Inggris) "Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II". Department of Biochemistry, University of California; Baudier J, Cole RD. Diakses tanggal 2010-06-27.

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[1] (Inggris) "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". Departments of Neurobiology and Immunology, University of Heidelberg; Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J. Diakses tanggal 2010-06-27.

[2] (Inggris) "alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356". Department of Medical Biochemistry, University of Aarhus; Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R. Diakses tanggal 2010-06-27.

[3] (Inggris) "14-3-3zeta is an effector of tau protein phosphorylation". Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University; Hashiguchi M, Sobue K, Paudel HK. Diakses tanggal 2010-06-27.

[4] (Inggris) "S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease". Centre for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto; Yu WH, Fraser PE. Diakses tanggal 2010-06-27.

[5] (Inggris) "Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II". Department of Biochemistry, University of California; Baudier J, Cole RD. Diakses tanggal 2010-06-27.

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